Food Intake, Body Weight Gain, and Body Composition of the Young Obese

ABSTRACT Estimates of food intake and body weight gain were ob
tained in obese (ob/ob) mice from 7 to 56 days of age. Milk intake was
estimated daily from 7 to 21 days of age; there were no differences between
obese and lean mice. From 14 to 21 days of age, obese mice gained more
body weight than lean mice. At 21 days of age, the carcasses of obese mice
contained about twice as much fat as the carcasses of lean mice did,
whereas the protein content was not different. Mice were weaned at 21
days of age, and individually fed a stock diet or a high-fat diet. During the
first several days after weaning, obese males consumed less food than did
the lean males. After approximately 28 to 35 days of age, obese mice con
sumed more food and gained more weight than lean mice. At 56 days of
age, obese mice contained 4 to 5 times as much body fat as did lean mice,
but contained significantly less body protein than lean mice. For the 5
week post-weaning period, obese mice converted 3 to 4 times more dietary
energy to body energy than did lean mice, whereas obese mice consumed
only 20 to 40% more energy. At the same time, obese mice converted only
about 70% as much dietary protein to body protein as did lean mice. The
high-fat diet markedly enhanced the apparent energy efficiency in obese
mice. The present studies suggest that alterations in energy metabolism,
as well as in protein metabolism, may play an important role in the develop
ment of obesity in these mice. Hyperphagia may be of secondary impor
tance. J. Nutr. 107: 1715-1723, 1977.


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